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5 from 1 vote

Turkey and Mushroom Casserole

Perfect for leftover turkey or rotisserie chicken, this creamy, cheesy and slightly tangy turkey and mushroom casserole is sure to be a crowd-pleaser.
Course Main, Main Course, Main Dish
Cuisine American
Keyword turkey casserole
Prep Time 15 minutes
Cook Time 50 minutes
Servings 8
Calories 660kcal
Author Liz Della Croce


  • 3 cups cooked turkey (or chicken) diced, such as rotisserie
  • 1 pound short cut pasta such as shells or penne cooked according to package instructions
  • 1 tablespoon butter
  • 1 cup diced onion
  • 2 teaspoons salt divided
  • 1 cup sliced mushrooms
  • 2 tablespoons flour
  • 2 cups chicken broth low sodium
  • 16 ounces whole milk plain yogurt
  • 2 cups shredded mozzarella cheese divided
  • 2 tablespoons lemon juice
  • 1 tablespoon Worcestershire sauce
  • 1/2 teaspoon pepper


  • Pre-heat oven to 350 degrees and spray a 9 x 13 baking pan with cooking spray.
  • Cook pasta according to package directions and set aside.
  • Heat butter in a large skillet over medium heat until melted. Stir in onion and 1 teaspoon of the salt. Cook until softened, 3-4 minutes before adding mushrooms. Continue cooking until mushrooms are soft, 3-4 additional minutes.
  • Sprinkle flour into the pan and stir for 30-60 seconds or until flour is absorbed into the pan. Pour in chicken broth and bring to a boil. Reduce heat to low and simmer until sauce thickens, 7-9 minutes.
  • In a large bowl, toss together cooked pasta with diced turkey, plain yogurt, remaining 1 teaspoon salt, half of the cheese (1 cup), lemon juice, Worcestershire sauce and pepper. Add in reduced mushroom sauce to the bowl and stir again.
  • Pour pasta mixture into the prepared baking dish and spread in an even layer. Sprinkle remaining cheese on top and bake until golden brown and bubbly, about 45-50 minutes. Let rest 5-10 minutes before serving to let the casserole settle.


Calories: 660kcal | Carbohydrates: 50g | Protein: 80g | Fat: 15g | Saturated Fat: 7g | Cholesterol: 191mg | Sodium: 1639mg | Potassium: 1075mg | Fiber: 2g | Sugar: 6g | Vitamin A: 348IU | Vitamin C: 8mg | Calcium: 273mg | Iron: 3mg